Daniela SCHULZ

Schulz, D. (2020).  Depression development: From lifestyle changes to motivational deficits.  Behavioural Brain Research, 395, 112845. doi: 10.1016/j.bbr.2020.112845.

Gold, M.E.L., Norell, M., Budassi, M., Vaska, P., Schulz, D. (2018).  Rapid ¹⁸F-FDG uptake in brain of awake, behaving rat and anesthetized chicken has implications for behavioral PET studies in species with high metabolisms.  Frontiers in Behavioral Neuroscience, 12, 115. doi: 10.3389/fnbeh.2018.00115.

Schulz, D. (2018).  Food deprivation separates motor-activating from anxiolytic effects of caffeine in a rat open field.  Behavioural Pharmacology, 29(6), 543-546.

Schulz, D. (2016).  Seasonal effects of the monoamine oxidase inhibitor deprenyl but not the tricyclic antidepressant imipramine in rats bred for helplessness.  Medical Science & Discovery, 3(8), 312-316.

Schulz, D., Henn, F.A., Petri, D., Huston, J.P. (2016).  Rats bred for helplessness exhibit positive reinforcement learning deficits which are not alleviated by an antidepressant dose of the MAO-B inhibitor deprenyl.  Neuroscience, 329, 83-92.

Gold, M.E.L., Schulz, D., Budassi, M., Gignac, P.M., Vaska, P., Norell, M.A. (2016).  Flying starlings, PET and the evolution of volant dinosaurs.  Current Biology, 26(7), R265-267.

Mirrione, M.M., Schulz, D., Lapidus, K., Zhang, S., Goodman, W., Henn, F.A. (2014).  Increased metabolic activity in the septum and habenula during stress is linked to subsequent expression of learned helplessness behavior.  Frontiers in Human Neuroscience, 8, 29.  doi:10.3389/fnhum.2014.00029

Ottis, P., Topic, B., Loos, M., Li, K.W., de Souza Silva, M.A., Schulz, D., Smit, A.B., Huston, J.P., Korth, C. (2013).  Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.  PLoS One, 8(9), e75112.

Huston, J.P., de Souza Silva, M.A., Komorowski, M., Schulz, D., Topic, B. (2013).  Animal models of extinction-induced depression: Loss of reward and its consequences.  Neuroscience & Biobehavioral Reviews, 37(9), 2059-2070.

Seese, R.R., Chen, L.Y., Cox, C.D., Schulz, D., Babayan, A.H., Bunney, W.E., Henn, F.A., Gall, C.M., Lynch, G. (2013).  Synaptic abnormalities in the infralimbic cortex of a model of congenital depression.  Journal of Neuroscience, 33(33), 13441-13448.

Schulz, D., Smith, D.S., Yu, M., Lee, H., Henn, F.A. (2013).  Selective breeding for helplessness in rats alters the metabolic profile of the hippocampus and frontal cortex: A ¹H-MRS study at 9.4 T.  International Journal of Neuropsychopharmacology, 16(1), 199-212. 

Schulz, D., Vaska, P. (2011).  The emerging discipline of behavioral neuroimaging.  Reviews in the Neurosciences, 22(6), 591-592.

Schulz, D., Vaska, P. (2011).  Integrating PET with behavioral neuroscience using RatCAP tomography.  Reviews in the Neurosciences, 22(6), 647-655.

Maramraju, S.H., Smith, S.D., Junnarkar, S.S., Schulz, D., Stoll, S., Ravindranath, B., Purschke, M., Rescia, S., Southekal, S.S., Pratte, J.-F., Vaska, P., Woody, C.L., Schlyer, D.J. (2011).  Small animal simultaneous PET/MRI: Initial experiences in a 9.4 T microMRI.  Physics in Medicine & Biology, 56(8), 2459-2480.

Schulz, D., Southekal, S., Junnarkar, S.S., Pratte, J.-F., Purschke, M.L., Stoll, S.P., Ravindranath, B., Maramraju, S.H., Krishnamoorthy, S., Henn, F.A., Woody, C.L., Schlyer, D.J., Vaska, P. (2011).  Simultaneous assessment of rodent behavior and neurochemistry using a miniature positron emission tomograph.  Nature Methods, 8(4), 347-352. 

Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C.D., Schulz, D., Henn, F.A., Malinow, R. (2011).  Synaptic potentiation onto lateral habenula neurons in the learned helplessness model of depression.  Nature, 470(7335), 535-539.

Von Wilmsdorff, M., Sprick, U., Bouvier, M.L., Schulz, D., Schmitt, A., Gaebel, W. (2010).  Sex-dependent behavioral effects and morphological changes in the hippocampus after prenatal invasive interventions in rats: Implications for animal models of schizophrenia.  Clinics, 65, 209-219.

Schulz, D., Mirrione, M., Henn, F.A. (2010).  Cognitive aspects of congenital learned helplessness and its reversal by the MAO-B inhibitor deprenyl.  Neurobiology of Learning and Memory, 93, 291-301.

Huston, J.P., Schulz, D., Topic, B. (2009).  Toward an animal model of extinction-induced depression: Focus on aging and physiological indices.  Journal of Neural Transmission, 116, 1029-1036.

Topic, B., Huston, J.P., Namestkova, K., Zhu, S.-W., Mohammed, A.H., Schulz, D. (2008).  Extinction-induced “despair” in aged and adult rats: Links to neurotrophins in frontal cortex and hippocampus.  Neurobiology of Learning and Memory, 90, 519-526.

Schulz, D., Aksoy, A., Canbeyli, R. (2008).  Behavioral despair is differentially affected by the length and timing of photic stimulation in the dark phase of an LD cycle.  Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32, 1257-1262.

Schulz, D., Huston, J.P., Buddenberg, T., Topic, B. (2007).  “Despair” induced by extinction trials in the water maze: Relationship with measures of anxiety in aged and adult rats.  Neurobiology of Learning and Memory, 87, 309-323.

Schulz, D., Buddenberg, T., Huston, J.P. (2007).  Extinction-induced “despair” in the water maze, exploratory behavior and fear: Effects of chronic antidepressant treatment.  Neurobiology of Learning and Memory, 87, 624-634. 

Schulz, D., Kouri, C., Huston, J.P. (2007).  Behavior on the water maze platform: Relationship to learning and open field exploration in aged and adult rats.  Brain Research Bulletin, 74, 206-215.

Sprick, U., von Wilmsdorff, M., Bouvier, M.-L., Schulz, D., Gaebel, W. (2006).  Behavioral and hippocampal changes after prenatal invasive interventions with possible relevance to schizophrenia.  Behavioural Brain Research, 172, 179-186. 

Sergeeva, O.A.*, Schulz, D.* (*equal contribution), Doreulee, N., Ponomarenko, A.A., Selbach, O., Borsch, E., Kircheis, G., Häussinger, D., Huston, J.P., Häussinger, D., Haas, H.L. (2005).  Deficits in cortico-striatal synaptic plasticity and behavioral habituation in rats with portacaval anastomosis.  Neuroscience, 134, 1091-1098.

Topic, B., Dere, E., Schulz, D., de Souza Silva, M.A., Jocham, G., Kart, E., Huston, J.P. (2005).  Aged and adult rats compared in acquisition and extinction of escape from the water maze: Focus on individual differences.  Behavioral Neuroscience, 119, 127-144.

Schulz, D., Topic, B., De Souza Silva, M.A., Huston, J.P. (2004).  Extinction-induced immobility in the water maze and its neurochemical concomitants in aged and adult rats: A possible model for depression?  Neurobiology of Learning and Memory, 82, 128-141. 

Schulz, D., Sergeeva, O.A., Ianovskii, E., Luhmann, H.J., Haas, H.L., Huston, J.P. (2004).  Behavioural parameters in aged rats are related to LTP and gene expression of ChAT and NMDA-NR2 subunits in the striatum.  European Journal of Neuroscience, 19, 1373-1383. 

Aksoy, A., Schulz, D., Yilmaz, A., Canbeyli, R. (2004).  Seasonal variability in behavioral despair in female rats.  International Journal of Neuroscience, 114, 1513-1520.

Jezek, K., Schulz, D., De Souza Silva, M.A., Müller, H.-W., Huston, J.P, Hasenöhrl, R.U. (2003).  Effects of chronic intraventricular infusion of heparin glycosaminoglycan on learning and brain acetylcholine parameters in aged rats.  Behavioural Brain Research, 147, 115-123.

Schulz, D., Huston, J.P. (2002).  The sliding window correlation procedure for detecting hidden correlations: Existence of behavioral subgroups illustrated with aged rats.  Journal of Neuroscience Methods, 121, 129-137.  

Schulz, D., Huston, J.P., Jezek, K., Haas, H.L., Roth-Härer, A., Selbach, O., Luhmann, H.J. (2002).  Water maze performance, exploratory activity, inhibitory avoidance and hippocampal plasticity in aged superior and inferior learners.  European Journal of Neuroscience, 16, 2175-2185.  

Yilmaz, A., Schulz, D., Aksoy, A., Canbeyli, R. (2002).  Prolonged effect of an anesthetic dose of ketamine on behavioral despair.  Pharmacology, Biochemistry and Behavior, 71, 341-344.

Schulz, D., Canbeyli, R. (2000).  Lesion of the bed nucleus of the stria terminalis enhances learned despair.  Brain Research Bulletin, 52, 83-87.

Schulz, D., Canbeyli, R. (1999).  Freezing behavior in BNST-lesioned Wistar rats.  Annals of the New York Academy of Sciences, 877, 728-731.

 

ABSTRACTS

Marks, K., Schulz, D., Mirrione M.M. (2021).  Analysis of CaMKII in brain homogenate from an animal model of depressive-like behavior treated with deprenyl.  Cognitive Neuroscience Society, Virtual Meeting.

Hajjar, A.J., Çakıcı, K., Küçük, M., Güçlü, B., Schulz, D. (2020).  Measuring effortful motivation with HEFFORT: Psychometric testing and validation using machine learning.  International Symposium on Brain and Cognitive Science – Ankara, Turkey.

Erkol, G., Biegon, A., Schulz, D. (2018).  Intravenous infusion of dopamine D2/D3 agonist PHNO decreases indicators of sexual motivation in female rats.  Federation of European Neuroscience Societies (FENS) – Berlin, Germany.

Schulz, D., Budassi, M, Kim, S.W., Muench, L., Fowler, J., Schlyer, D., Vaska, P. (2018).  Further validation of the behavioral neuroimaging approach using RatCAP tomography, [11C]PHNO, and a paced mating paradigm.  Federation of European Neuroscience Societies (FENS) – Berlin, Germany.

Firat, Z., Ture, U., Ozturk-Isik, E., Sarsilmaz, A., Ozdeniz, E., Schulz, D. (2017). Diffusion tensor imaging as a tool to predict memory deficits in left temporal lobe patients.  European Society of Radiology – Vienna, Austria.

Gold, M.E.L., Schulz, D., Budassi, M., Vaska, P., Gignac, P., Norell, M. (2016).  Applying dice-CT to PET: New tools for correlating morphology to function in living animals.  International Congress of Vertebrate Morphology – Washington D.C, USA.

Schulz, D., Petri, D., Huston, J.P., Henn, F.A. (2015).  Positive reinforcement learning is impaired in rats bred for helplessness and not reversible by monoamine oxidase (MAO)-B inhibitor deprenyl.  Society for Neuroscience – Chicago, USA. 

Ottis, P., Topic, B., Loos, M., Li, K.W., Desouza, A., Schulz, D., Smit, B., Huston, J.P., Korth, C. (2013).  Age-associated insoluble hippocampal proteins involved in synaptic plasticity correlate with learning behavior in a rat model for MCI.  Society for Neuroscience – San Diego, USA. 

Maramraju, S.H., Smith, S.D., Stoll, S., Schulz, D., Rescia, S., Junnarkar, S., Purschke, M., Ravindranath, B., Vaska, P., Woody, C., Schlyer, D. (2011).  Simultaneous PET/MRI: Evaluation of electromagnetic interactions and in vivo imaging in 9.4 T MRI.  International Society for Magnetic Resonance in Medicine – Montréal, Québec, Canada.  Proc. Intl. Soc. Mag. Reson. Med., 19, 3800.

Schulz, D., Southekal, S., Henn, F.A., Schlyer, D., & Vaska, P. (2010).  Simultaneous assessment of D2 receptor occupancy and spontaneous behavioral activity using the RatCAP tomograph.  Society for Neuroscience – San Diego, USA.

Maramraju, S.H., Smith, S.D., Stoll, S., Schulz, D., Purschke, M., Ravindranath, B., Junnarkar, S.S., Vaska, P., Woody, C.L., & Schlyer, D.J. (2010).  Simultaneous PET/MR imaging results of a rat brain and a mouse heart with an MRI compatible PET detector in a 9.4 T microMRI.  Society for Nuclear Medicine – Salt Lake City, USA.

Smith, S.D., Maramraju, S.H., Southekal, S., Ravindranath, B., Krishnamoorthy, S., Purschke, M., Junnarkar, S., Rescia, S., Schulz, D., Woody, C., Stoll, S., Vaska, P., Carrion, J., Schlyer, D., & Benveniste, H. (2010).  Simultaneous acquisition of MRI and PET cardiac cine 3D images at 9.4 Tesla.  Journal of Cardiovascular Magnetic Resonance, 12, O59. 

Schulz, D., Southekal, S., Schiffer, W., Henn, F.A., Schlyer, D., & Vaska, P. (2009).  PET imaging in behaving animals with the RatCAP tomograph.  American College of Neuropsychopharmacology – Florida, USA.

Mirrione, M.M., Schulz, D., Dewey, S., & Henn, F.A. (2009).  Medial thalamic activation following inescapable shock correlates with subsequent learned helpless behavior.  American College of Neuropsychopharmacology – Florida, USA.

Schulz, D., Southekal, S., Schiffer, W., Henn, F.A., Schlyer, D., & Vaska, P. (2009).  The RatCAP portable scanner: Towards PET imaging in behaving animals.  International Behavioral Neuroscience Society – Nassau, Bahamas.

Schulz, D., Southekal, S., Junnarkar, S., Maramraju, S., Schiffer, W., Krishnamoorthy, S., Purschke, M., Vaska, P., Woody, C., & Schlyer, D. (2009).  11C-Raclopride kinetics in awake and anesthetized rats using the RatCAP awake rat brain PET.  Society for Nuclear Medicine – Toronto, Canada.

Southekal, S., Schulz, D., Schlyer, D., Junnarkar, S., Maramraju, S., Ravindranath, B., Stoll, S., Pratte, J.-F., Purschke, M., Woody, C., & Vaska, P. (2009).  Quantitative dynamic neuroimaging with the RatCAP.  IEEE Nuclear Science Symposium and Medical Imaging Conference – Florida, USA.

Maramraju, S.H., Smith, S.D., Rescia, S., Junnarkar, S.S., Ravindranath, B., Stoll, S., Purschke, M., Schulz, D., Southekal, S.S., Lenz, B., Pratte, J.-F., Vaska, P., Woody, C.L., & Schlyer, D.J. (2009).  Simultaneous acquisition of PET/MR images of small animals at 9.4 T.  IEEE Nuclear Science Symposium and Medical Imaging Conference – Florida, USA.

Vaska, P., Kim, D.-H,, Southekal, S., Krishnamoorthy, S., Stoll, S., Fried, J., Schulz, D., Pratte, J.-F., Dragone, A., Cui, Y.-G., DeGeronimo, G., Bolotnikov, A., Woody, C.L., & O’Connor, P. (2009).  Performance of a prototype ultra-high resolution PET scanner using CZT pixel detectors.  IEEE Nuclear Science Symposium and Medical Imaging Conference – Florida, USA.

Mirrione, M.M., Schulz, D., Dewey, S., & Henn, F.A. (2008). Metabolic imaging in the learned helplessness model of depression implicates the habenula in altered neurocircuitry.  American College of Neuropsychopharmacology – Arizona, USA.

Schulz, D., Mirrione, M.M., & Henn, F.A. (2008).  Behavioral concomitants of congenital learned helplessness and its reversal by a monoamine oxidase B inhibitor.  Society for Neuroscience – Washington D.C., USA.

Mirrione, M.M., Schulz, D., & Henn, F.A. (2008). Imaging neuronal activity in the learned helplessness model of depression using 18FDG microPET.  Society for Neuroscience – Washington D.C., USA.

Henn, F.A., Schulz, D., Mirrione, M.M., & Zink, M. (2008).  Circuits and cells: The role of glutamate in sustaining learned helplessness.  Symposium on glutamate evoked excitation: New evidence of glutamate’s role in the pathophysiology of mood disorders provides new targets for drug development. Collegium Internationale Neuro-Psychopharmacologicum – Munich, Germany. 

Vaska, P., Woody, C., Schlyer, D., Junnarkar, S., Southekal, S., Schulz, D., Pratte, J.-F., Stoll, S., Purschke, M., Fried, J., Schiffer, W., Maramraju, S., Ravindranath, B., Krishnamoorthy, S., Radeka, V., O’Connor, P., Lecomte, R., & Fontaine, R. (2008).  Physics performance and quantitative brain imaging studies using the RatCAP tomograph.  IEEE Nuclear Science Symposium and Medical Imaging Conference – Dresden, Germany. 

Schlyer, D., Vaska, P., Woody, C., Schulz, D., Junnarkar, S., Southekal, S., Maramraju, S., Schiffer, W., & Alexoff, D. (2008).  Comparison of [11C]raclopride kinetics in awake and anesthetized rats using the RatCAP awake rat brain PET system.  Society for Nuclear Medicine – New Orleans, USA.

Vaska, P., Woody, C., Schlyer, D., Pratte, J.-F., Junnarkar, S., Southekal, S., Stoll, S., Schulz, D., Schiffer, W., Alexoff, D., Lee, D., Patel, V., Purschke, M., Lee, W., Fried, J., Lenz, W., Krishnamoorthy, S., Maramraju, S., Kriplani, A., Radeka, V., O’Connor, P., Lecomte, R., & Fontaine, R. (2007).  The design and performance of the 2nd-generation RatCAP awake rat brain PET system.  IEEE Nuclear Science Symposium Conference Record, 6, 4181-4184.

Schulz, D., Huston, J.P., Buddenberg, T., & Topic, B. (2006).  Extinction-induced despair in the water maze and its relationship with anxiety in aged and adult rats.  Society for Neuroscience – Atlanta, USA.

Topic, B., Huston, J.P., Zhu, S.-W., Mohammed, A.H., & Schulz, D. (2006).  Neurotrophin protein levels in frontal cortex and hippocampus correlate with extinction-induced despair in the water maze in aged and adult rats.  Society for Neuroscience – Atlanta, USA.

Schulz, D., Kouri, C., Topic, B., & Huston, J.P. (2005).  Platform behavior in the water maze and its correlates with spatial and procedural learning in aged and adult rats.  Society for Neuroscience – Washington D.C., USA.

Schulz, D., Topic, B., De Souza Silva, M.A., & Huston, J.P. (2004).  Extinction-induced despair in the water maze: Promise of a conceptual and empirical model of human depression.  International Behavioral Neuroscience Society – Florida, USA.

Topic, B., Jocham, G., Kart, E., Schulz, D., De Souza Silva, M.A., & Huston, J.P. (2004).  Individual differences in water maze performance and open field behavior in aged and adult rats.  International Behavioral Neuroscience Society – Florida, USA.

Schulz, D., Kouri, C., Topic, B., De Souza Silva, M.A., & Huston, J.P. (2003).  Water maze extinction as a model of depression in aged and young rats: interaction of extinction-induced despair with learning ability and striatal neurotransmitters.  Society for Neuroscience – New Orleans, USA.

Topic, B., Jocham, G., Schulz, D., Steenbergen, P.J., Oitzl, M.S., Meijer, O.C., & Huston, J.P. (2003).  Expression of central corticosteroid receptor mRNA in adult and aged rats differs not only as a function of age but also as a function of water maze performance.  Society for Neuroscience – New Orleans, USA.

Schulz, D., Topic, B., & Huston, J.P. (2003).  Water maze extinction as a model of depression in aged and young rats: interaction of extinction-induced despair with learning ability.  European Brain and Behaviour Society – Barcelona, Spain.

Schulz, D. & Huston, J.P. (2002).  The sliding window correlation procedure for detecting hidden correlations: Existence of subgroups with differing behavioral phenotype as illustrated with aged rats.  3rd Symposium on the Molecular Bases of Learning and Memory – Berlin, Germany.

Schulz, D., De Souza Silva, M.A., Holling, C., Huston, J.P., Haas, H.L., & Sergeeva, O.A. (2002).  Variability in water maze learning in relation to hippocampal NMDA-receptor subunit expression, serotonin turnover and acetylcholine in aged and adult rats.  Federation of European Neuroscience Societies Forum – Paris, France.

Topic, B., Jocham, G., Schulz, D., De Souza Silva, M.A., & Huston, J.P. (2002).  Neurochemical and behavioral concomitants of extinction of water maze escape behavior in old and adult rats.  International Behavioral Neuroscience Society – Napels, Italy.

Schulz, D. & Huston, J.P. (2001).  Behavioural and physiological concomitants of superior and inferior learning in aged rats.  Behavioural Pharmacology, 12 (Suppl 1), S93.

Schulz, D., Huston, J.P., Luhmann, H.L., Yanovsky, Y., Haas, H.L., & Sergeeva, O. (2001).  Striatal ChAT correlates with learning rates whereas LTP and STP correlate with learning levels in aged rats which perform superior in the water maze.  Society for Neuroscience - San Diego, USA.

De Souza Silva, M.A., Jezek, K., Schulz, D., Weth, K., Müller, H.W., Huston, J.P., & Hasenöhrl, R.U. (2001).  Facilitation of learning and modulation of frontal cortex acetylcholine by heparin glycosaminoglycan.  Society for Neuroscience - San Diego, USA. 

Schulz, D., Haas, H.L., Yanovsky, Y., Luhmann, H.J., & Huston, J.P. (2001).  Exploration and Morris maze performance in aged rats both correlate with hippocampal and striatal STP and LTP.  International Behavioral Neuroscience Society - Cancun, Mexico.

Schulz, D., Huston, J.P., Jezek, K., Haas, H.L., Yanovsky, Y., Roth-Härer, A., Selbach, O., & Luhmann, H.J. (2000).  Water maze learning in aged rats correlates with short- and long-term potentiation in the hippocampus and striatum.  Society for Neuroscience - New Orleans, USA.

Canbeyli, R., Babacan-Yildiz, G., Schulz, D., Aksoy, A., Tataroglu, O, & Yilmaz, A. (1999).  Time-dependent effect of ketamine on forced swim tests in male Wistar rats.  Society for Neuroscience - Miami, USA.

Schulz, D. & Canbeyli, R. (1998).  Assessment of learned despair and freezing behavior in BNST lesioned Wistar rats.  New York Academy of Sciences - Virginia, USA.

Schulz, D., Celikel, T., & Canbeyli, R. (1998).  Effect of BNST lesions on learned despair as measured by forced swimming tests in male Wistar rats.  Society for Neuroscience - Los Angeles, USA.

Canbeyli, R., Celikel, T., Hasanoglu, A., Schulz, D., & Geissler, A.E. (1997).  Depressant effect of bilateral lesions of suprachiasmatic nuclei in rats as measured by the forced swimming test.  Society for Neuroscience - New Orleans, USA.

Canbeyli, R., Celikel, T., Akin, O., Schulz, D., Cansiz, S., Celen, H., Eslen, H., & Sohtorik, Y. (1997).  Differential effect of different tone sequences on the forced swim performance of female rats.  European Psychology Congress - Dublin, Ireland.