Kurtuluş GÖKDUMAN

Rank & Status: 

Ph.D.

Biography: 

Dr. Kurtulus Gokduman received his B.Sc. degree in Biology, M.Sc. degree in Biotechnology, and Ph.D. degree in Biotechnology from Middle East Technical University, Ankara, Turkey. During his Ph.D. studies, he focused on the development of molecular genetic tools for Salmonella detection, as well as on the development of targeted and sustained delivery of Camptothecin anticancer drugs in bioactive form using iron oxide micro and nanoparticles. These researches have led to several publications and national/international patent applications.

He performed post-doctoral research at Harvard Medical School, Harvard University, Boston, MA-USA, on the investigation of hepatotoxicity profiles of superparamagnetic iron oxide nanoparticles using primary hepatocyte models in static conditions as well as in dynamic liver-on-a-chip platforms.

Currently, his researches focus on micro/nano-systems for biomedical applications, involving tumor/organ-on-a-chip, in vitro diagnostic, nanotheranostic, nanomolecular medicine and nanotoxicology studies.

 

Education: 

Ph.D. in Biotechnology, Middle East Technical University, Ankara-TURKEY (2012)

M.Sc. in Biotechnology, Middle East Technical University, Ankara-TURKEY (2005)

B.Sc. in Biology, Middle East Technical University, Ankara-TURKEY (2003)

Research Areas: 

Micro-Systems for Biomedical Applications

•Development of tumor-on-a-chip platforms to test the efficacy of the drugs or nano delivery systems for the drugs

•Development of organ-on-a-chip platforms to test the side effects of the drugs or nano delivery systems for the drugs

•Development of microfluidic systems for diagnostic applications

 

Nano-Systems for Biomedical Applications

•Nanotheranostic studies to develop nano-systems allowing simultaneous diagnostic imaging and therapy  

•Nanomolecular medicine studies to investigate biological interactions of nanomaterials

•Nanotoxicology studies to investigate toxicological profiles of nanomaterials

 

Publications: 

PATENTS

Kurtulus Gokduman, Duran Ustek, Candan Gurakan. Method of Detection and Quantification of Salmonella Pathogen Using Molecular Genetic Device and Device Thereof. International patent application (PCT application), (Application number: PCT/TR2013/000165; Publication number/date: WO2014185870 A1/Nov 20, 2014).
 
Kurtulus Gokduman, Duran Ustek, Candan Gurakan. Method of Detection and Quantification of Salmonella Pathogen Using Molecular Genetic Device and Device Thereof. National patent number/date: TR 2015 07196 B/June 21, 2016.
 
 
 
REFEREED JOURNAL PAPERS
 
*Denotes corresponding author.
 
Kurtulus Gokduman*. Comparison of the Effect of Magnetite (Fe3O4) Iron Oxide Nanoparticles on Melanoma Cells and Healthy Cells: An In Vitro Study. Letters in Applied NanoBioScience, 2020, 9(2): 1049-1057.
 
Kurtulus Gokduman*, Asiye Gok. In vitro Investigation of Therapeutic Potential of Bare Magnetite (Fe3O4) Nanoparticles (≤100 ppm) on Hepatocellular Carcinoma Cells (HepG2). Journal of Nanoscience and Nanotechnology, 2020, 20(3): 1391-1400.
 
Kurtulus Gokduman*. Sensitization of Cisplatin-Resistant Ovarian Cancer Cells to Cisplatin by Magnetite (Fe3O4) Iron Oxide Nanoparticles: An In Vitro Study. Nanomedicine (5-Year Impact Factor: 5.217 (2018)), 2019, 14(24): 3177-3191.
 
•Lei Li, Kurtulus Gokduman*, Martin L. Yarmush, O. Berk Usta*. A Microfluidic 3D Hepatocyte Chip for Hepatotoxicity Testing of Nanoparticles. Nanomedicine (5-Year Impact Factor: 5.217 (2018)), 2019, 14(16): 2209-2226.
 
Kurtulus Gokduman*. In vitro Investigation of Anti-cancer Activity of Propolis on Hepatocellular Carcinoma Cells. Medicine Science, 2019, 8(3): 557-562. 
 
Kurtulus Gokduman*, Furkan Bestepe, Lei Li, Martin L. Yarmush, O. Berk Usta*. Dose, Treatment and Time Dependent Toxicity of Superparamagnetic Iron Oxide Nanoparticles on Primary Rat Hepatocytes. Nanomedicine (5-Year Impact Factor: 5.217 (2018)), 2018, 13(11): 1267-1284.
 
Kurtulus Gokduman*. Strategies Targeting DNA Topoisomerase I in Cancer Chemotherapy: Camptothecins, Nanocarriers for Camptothecins, Organic Non-Camptothecin Compounds and Metal Complexes. Current Drug Targets (IF (2017): 3.112), 2016, 17(16): 1928-1939.
 
Kurtulus Gokduman*, Dilek Avsaroglu, Aris Cakiris, Duran Ustek, G. Candan Gurakan. Recombinant Plasmid-Based Quantitative Real-Time PCR Analysis of Salmonella enterica Serotypes and Its Application to Milk Samples. Journal of Microbiological Methods, 2016, 122: 50-58. 
 
Kurtulus Gokduman*, Ayhan S. Demir. Camptothecin Anticancer Drug Loaded Iron Oxide Micro and Nanoparticles: Tuning Targeted and Sustained Release of the Drug in Bioactive Form. Current Nanoscience, 2013, 9(6): 704-710.
 
•Feride Severcan, Kurtulus Gokduman, Ayca Dogan, Sukran Bolay, Saadet Gokalp. Effects of In-Office and At-Home Bleaching on Human Enamel and Dentin: An in vitro Application of Fourier Transform Infrared Study. Applied Spectroscopy, 2008, 62(11): 1274-1279.
 
•Ayca Dogan, Kurtulus Gokduman, Sukran Bolay, Feride Severcan. Evaluation of In-Office Bleaching on Enamel and Dentine: An FTIR Study. WSEAS Transactions on Biology and Biomedicine, 2005, 2(4): 365-369.
 
Reviewer for: 

•Oncotarget

•Current Drug Targets

•Anti-Cancer Agents in Medicinal Chemistry 

•Nanobiomedicine

•Nanomaterials and Nanotechnology

E-Mail: 
kurtulus.gokduman@gmail.com