New TÜBİTAK 2232 International Fellowship for Outstanding Researchers Program Project of Dr. Savaş Taşoğlu at the Institute of Biomedical Engineering
28% of all primary brain tumors and central nervous system tumors and 80% of malignant tumors are gliomas, which arise from the supportive tissues in the brain. Yet, our ability to effectively treat these cancers is limited by our knowledge of the disease and our ability to test new treatments on accurate models. Current methods of biological research rely on animal testing and two-dimensional tissue cultures but fail to provide physiologically accurate models of human tissue. This demonstrates a pressing need for convenient, physiologically relevant tissue models to advance biomedical research. Advances in microfluidics and cell encapsulation within hydrogels have made significant strides in trying to meet these needs, but the potential to use these technologies for engineering physiologically relevant tissue models has yet to be fully realized. Here, we propose to investigate cancer biology using a microfluidic device with three-dimensional (3D) micro-patterned cellular constructs that may be subjected to flow through microfluidic channels. This microphysiological platform takes advantage of microfluidics, cell encapsulation within 3D constructs, and microscale patterning of different cell types. This work will yield a spatially patterned co-culture microenvironment which accurately mimics the physiological conditions of glioma. Using the developed model, we aim to understand the cellular gliomagenesis, glioma cell migration, and angiogenesis and further test drug susceptibility to demonstrate the relevance of the proposed model. For further information, please reach to T-Lab Website.
We are looking for 5 highly motivated, creative and self-initiative students to join us as M.Sc. or (preferably) Ph.D. students for the Spring 2020 semester (Feb. 2020) or Fall 2020. Interested students are expected to have strong background or demonstrated interest in either engineering (e.g. robotics, system integration, micro-fabrication, biomanufacturing etc.) or biological sciences (cell/tissue culture, immunochemistry, animal research etc.). Strong background in both is not expected. Please see the job ad.